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Yes, byssi is a Scrabble word!
...and is worth 10 points in Scrabble, and 10 points in Words with Friends
1. Tuft of strong filaments by which e.g. a mussel makes itself fast to a fixed surface
What Scrabble words can I make with the letters in byssi?
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Words that can be created with an extra letter added to byssi: