Yes, define is a Scrabble word!
...and is worth 10 points in Scrabble, and 11 points in Words with Friends
define
Verb
1. Determine the essential quality of
2. Give a definition for the meaning of a word
3. Determine the nature of
4. Show the form or outline of
5. Decide upon or fix definitely
What Scrabble words can I make with the letters in define?
5 Letter Words
4 Letter Words
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3 Letter Words
2 Letter Words