Yes, girls is a Scrabble word!
...and is worth 6 points in Scrabble, and 8 points in Words with Friends
girls
Noun
1. A young woman
2. A youthful female person
3. A female human offspring
4. A girl or young woman with whom a man is romantically involved
5. A friendly informal reference to a grown woman
What Scrabble words can I make with the letters in girls?
4 Letter Words
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3 Letter Words
2 Letter Words