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Yes, mezzo is a Scrabble word!
...and is worth 25 points in Scrabble, and 26 points in Words with Friends
1. A soprano with a voice between soprano and contralto
2. The female singing voice between contralto and soprano
What Scrabble words can I make with the letters in mezzo?
2 Letter Words
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Words that can be created with an extra letter added to mezzo: