Yes, mouthful is a Scrabble word!
...and is worth 16 points in Scrabble, and 19 points in Words with Friends
mouthful
Noun
1. The quantity that can be held in the mouth
2. A small amount eaten or drunk
What Scrabble words can I make with the letters in mouthful?
5 Letter Words
4 Letter Words
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3 Letter Words
2 Letter Words