Yes, nicest is a Scrabble word!
...and is worth 8 points in Scrabble, and 10 points in Words with Friends
nicest
Adjective
1. Pleasant or pleasing or agreeable in nature or appearance
2. Socially or conventionally correct; refined or virtuous
3. Done with delicacy and skill
4. Excessively fastidious and easily disgusted
5. Exhibiting courtesy and politeness
What Scrabble words can I make with the letters in nicest?
6 Letter Words
5 Letter Words
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3 Letter Words
2 Letter Words