Yes, nisus is a Scrabble word!
...and is worth 5 points in Scrabble, and 7 points in Words with Friends
nisus
Noun
1. An effortful attempt to attain a goal
What Scrabble words can I make with the letters in nisus?
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1 Anagram of Nisus
Words that can be created with an extra letter added to nisus:
T:suints