Yes, setup is a Scrabble word!
...and is worth 7 points in Scrabble, and 9 points in Words with Friends
setup
Noun
1. Equipment designed to serve a specific function
2. The way something is organized or arranged
3. An act that incriminates someone on a false charge
What Scrabble words can I make with the letters in setup?
5 Letter Words
4 Letter Words
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3 Letter Words
2 Letter Words