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Yes, mono is a Scrabble word!
...and is worth 6 points in Scrabble, and 8 points in Words with Friends
1. Designating sound transmission or recording or reproduction over a single channel
1. An acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream; not highly contagious; some believe it can be transmitted by kissing
What Scrabble words can I make with the letters in mono?
4 Letter Words
3 Letter Words
2 Letter Words