Yes, uncle is a Scrabble word!
...and is worth 7 points in Scrabble, and 11 points in Words with Friends
uncle
Noun
1. The brother of your father or mother; the husband of your aunt
2. A source of help and advice and encouragement
What Scrabble words can I make with the letters in uncle?
4 Letter Words
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3 Letter Words
2 Letter Words