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Yes, vexes is a Scrabble word!
...and is worth 15 points in Scrabble, and 16 points in Words with Friends
1. Cause annoyance in; disturb, especially by minor irritations
2. Disturb the peace of mind of; afflict with mental agitation or distress
3. Change the arrangement or position of
4. Subject to prolonged examination, discussion, or deliberation
5. Be a mystery or bewildering to
What Scrabble words can I make with the letters in vexes?
4 Letter Words
3 Letter Words
2 Letter Words