Yes, safe is a Scrabble word!
...and is worth 7 points in Scrabble, and 7 points in Words with Friends
safe
Adjective
1. Free from danger or the risk of harm
2. (of an undertaking) secure from risk
3. Having reached a base without being put out
4. Financially sound
Noun
1. Strongbox where valuables can be safely kept
2. A ventilated or refrigerated cupboard for securing provisions from pests
3. Contraceptive device consisting of a sheath of thin rubber or latex that is worn over the penis during intercourse
What Scrabble words can I make with the letters in safe?
3 Letter Words
2 Letter Words