Yes, gypsum is a Scrabble word!
...and is worth 14 points in Scrabble, and 17 points in Words with Friends
gypsum
Noun
1. A common white or colorless mineral (hydrated calcium sulphate) used to make cements and plasters (especially plaster of Paris)
What Scrabble words can I make with the letters in gypsum?
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Words that can be created with an extra letter added to gypsum:
S:gypsums