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Yes, ires is a Scrabble word!
...and is worth 4 points in Scrabble, and 4 points in Words with Friends
1. A strong emotion; a feeling that is oriented toward some real or supposed grievance
2. Belligerence aroused by a real or supposed wrong (personified as one of the deadly sins)
What Scrabble words can I make with the letters in ires?
4 Letter Words
3 Letter Words
2 Letter Words