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Yes, signior is a Scrabble word!
...and is worth 8 points in Scrabble, and 10 points in Words with Friends
1. Used as an Italian courtesy title; can be prefixed to the name or used separately
What Scrabble words can I make with the letters in signior?
7 Letter Words
6 Letter Words
5 Letter Words
4 Letter Words
3 Letter Words
2 Letter Words