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Yes, sprain is a Scrabble word!
...and is worth 8 points in Scrabble, and 10 points in Words with Friends
1. Twist suddenly so as to sprain
1. A painful injury to a joint caused by a sudden wrenching of its ligaments
What Scrabble words can I make with the letters in sprain?
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Words that can be created with an extra letter added to sprain: